POS1367 PROCALCITONIN IN RHEUMATOLOGY

Background: The differentiation between infection and aseptic inflammation is difficult often a challenge in the daily practice of rheumatology.Procalcitonin (PCT) preferred marker for bacterial infections that allows rheumatologist to make an early diagnosis, choose appropriate antibiotic therapy infection, avoid unnecessary inflammation. Objectives: To study levels PCT various inflammatory states observed rheumatology department, assess its possible discriminating role from other processes. Methods: This preliminary monocentric retrospective conducted January 2018 December 2020 our department. inclusion criteria were all patients hospitalized rheumatic or autoimmune disease bone joint infection.PCT samples analyzed along with general signs (fever/chills) routine assessment (blood count including white blood cell count(WBC), erythrocyte sedimentation rate (ESR)and C reactive protein(CRP)) admitted hospitalfor fever biological syndrome, both, laboratory cut-off value 0.5 ng/ml. Results: 20 included. Their mean age was 46.1 (extremes 19 – 66)and sex ratio 1. Three had history disease, 2 neoplasia, 1 chronic terminal kidney failure hemodialysis, 4 took antibiotics before hospitalization. 100.01ng/ml 0.01-200), Sensitivity at 57.44% specificity 100%, PPV: NPV: 81.25%. divided according their final diagnosis into 3 groups: fungal infection; abacterian (autoimmune flare, metabolic, arthritis); + disease. Group included patients, 6.92ng/ml (0.16-26.80),mean CRP 131.725 mg/L, ESR 50 mm, 25% hyperleukocytosis.2 already taken admission. 13 0.025 ng/mL (0.01-0.13), 132.25mg/L, 84.38mm, 30.77% them hyperleukocytosis. 66.88 (0.02-200), 560 107.33 33.33% hyperleucocytosis. patient highest sepsis uremic encephalopathy improved after hemodialysis. A control made who received antibiotics,showing decrease negativation compared initial PCT. Conclusion: Our showed only increased significantly infections. values more than level WBC differentiating another process, hence using this case doubt. 1(n=4 ) 2(n=13 3(n=3 Mean 45 46.77 44.67 Sex M/F 2/2 8/5 0/3 Reason hospitalization Phlegmon left shoulder gonalgia feverish context Multiple vertebral fractures Acute monoarthritis knee Pain hip functional impairment Inflammatory polyarthralgia15.38% back pain 23.07% Activity his 15.38% Chronic 7.69% febrile polyarthralgia Biarthritis 66.67% Flare polymyalgia rheumatica History Neoplasia Autoimmune End-stage renal hemodialysis indication Suspected septic arthritis 75% Exploration syndrome Suspicion 46.15% 53.85% (ng/ml 6.92 fever/chills Biological parameters Hyperleukocytosis (mm (mg/L 30.77 % 84.38 132.25 Disclosure Interests: None declared